Highland plains people AVP gene polymorphism and the relationship between hypoxic adaptation

摘要

Objective To investigate the plateau plains of arginine vasopressin (AVP) gene polymorphism population and hypoxic adaptation in the relationship. Methods Polymerase chain reaction and restriction fragment length polymorphism method, the indigenous Tibetan population and plains Han Chinese AVP gene polymorphism detection and analysis of genotype and allele distribution. Results Showed that 150 cases of native Tibetans in +22959 sites GG, GT, TT distribution of genotype frequencies were 46%, 50.1% and 3.3%, while the plain Han people 60.%, 37.3% and 4.7%, the difference was statistically significant (P <0.05); Tibetan plateau alleles G, T in the distribution frequency of 67.4% and 32.6,% and 82.2% and 17.8% plains of the Han people, the difference Statistically significant (P <0.05), Tibetan Plateau T mutation was significantly higher than the Han plain. -2041 site of the genotypes and allele distribution between the two groups was not significant. Conclusion The frequencies of + 22959 polymorphic genotypes and alleles showed statistically significant difference between the high altitude group and the plain Han people (P< 0.05) Genetic single nucleotide polymorphism in G +22959 T may be associated with the adaptation to high altitude hypoxia．