Preparation and recognition properties of levodropopizine molecularly imprinted composite membranes

摘要

Thin-layer molecularly imprinted composite membranes for selective binding and permeation of levodropopizine were developed via thermal-initiated surface modification of polyvinylidene fluoride microfiltration membranes. ATR-FTIR was used to analyze the surface structures of these membranes. Binding experiments revealed that the saturated binding capacity of MICM was 75.746 umol/g, nearly 3 times higher than that of NICM. Scatchard analysis showed that binding specificity of MICM was a result of multi-site binding to the template. The selective factor of LDPZ and 1-phenylpiperazine was 2.344 in competitive permeation studies. The permeation mechanism of LDPZ imprinted membranes could be inferred as facilitated permeation mechanism.