Effects of zinc gluconate on copper, iron and calcium levels in patients with type 2 diabetes mellitus

摘要

We evaluated the effects of three different single doses of zinc gluconate (15, 25 and 50 mg) on serumcopper, iron and calcium levels in patients with type 2 diabetes mellitus (T2DM). Laboratory parameters weremeasured in patients (n=12) and healthy individuals (n=12). The calcium level were found to be significantdecreased 24h after zinc administration in dose of 50 mg in T2DM patients compared with the baseline valuemarked before treatment (p<0,05). The Cu/Zn ratio were significantly lower in T2DM patients 24h after zincadministration in doses of 25 and 50 mg compared with baseline values (p<0,05). Based on obtained results itcan be observed that administration of zinc gluconate in single higher doses showed reduction of serum calciumlevel and Cu/Zn ratio only in T2DM.