Early Autonomic Cardiovascular Dysregulation in Young Healthy Adults with Family History for Increased Cardiovascular Risk

摘要

This study was aimed at showing the existence of early and subtle autonomic dysregulation in young normotensive individuals with family history for cardiovascular risk (N+) as compared to their age matched controls (C). The deep breathing test (DBT) was applied as stimulus of heart rate variability (HRV); brachial-ankle pulse wave velocity (ba-PWV) was evaluated as marker of arterial stiffness. Two methods for HRV evaluation were applied: fast Fourier transform (FFT) and wavelet transform (WT). At baseline, (N+) showed lower HRV; DBT produced larger stimulation of HRV in C. Ba-PWV was higher in (N+). Our data revealed discreet sympathetic predominance in (N+) shown by the altered HRV as well as by the higher ba-PWV. WT allowed a more detailed analysis of HRV dynamics as compared to FFT.