UTILIZING DISSIPATIVE MICROBALANCE TECHNOLOGY (QCM-D) to Quantify Coating Degradation PROCESSES AND ELUCIDATE A MORE FUNDAMENTAL UNDERSTANDING OF HOW BLOOD-BORNE MOLECULES INTERACT WITH IMPLANT COATINGS

摘要

Quantitatively understanding how implant materials behave . in-situ is becoming more and more relevant as researchers and engineers are being challenged to design new materials that provide novel property enhancements. Here we will review work that we have done utilizing the dissipative microbalance technology (QCM-D) to quantify how materials behave in-situ. By utilizing QCM-D we can assess both mass and structural changes in a coating or molecule at an interface. We will discuss recent work that demonstrates how QCM-D can follow phenomena such as controlled release of a coating and also present recent findings that show how we are able to quantify how blood-borne molecules interact with different surface chemistries.