The organization of proteins into complexes is of great importance for their function (7). Several classes of protein receptors, such as growth factor receptors and ion channels, need to form dimers or even larger oligomeric structures to effectuate transfer of a biochemical signal across the cell membrane. Specific families of eukaryotic transcription factors bind to DNA as dimers through recognition of palindromic DNA sequences (2). Additionally, many enzymes are organized into macromolecular complexes.
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