Effects of phytic acid on cell proliferation and apoptosis

摘要

Effects of phytic acid, inositol hexaphosphate (IP6), on reactive oxygen species and reproductive efficiency of cells were studied. Low concentration of phytic acid (< 5 mM) induced both the arrest of cell cycle and the decrease of naturally occurring apoptosis. On the other hand, high concentration of phytic acid (> 5 mM) increased apoptotic cells. In vitro systems, whereas low concentration of phytic acid inhibited the formation of superoxide and hydroxyl radical, high concentration (> 5 mM) of phytic acid enhanced the generation of hydroxyl radical. Incubation with high concentration (10 mM) of phytic acid also produced hydroxyl radical in PLB-985 cells.