IMMUNE MONITORING IN ALLOGRAFT RECIPIENT WITH MINIMAL IMMUNESUPPRESSION

摘要

In transplant patients, the cost associated with the extended immunosuppressive medication is often the limiting factor that determines the success of graft survival and function. We are involved in an investigational protocol to stimulate the recipient with the donor antigens then do clonal deletion before the transplant, with the intention of minimizing post-transplant immune mediated graft rejection. Donor specific HLA antigen- antibody reactions are mainly responsible for graft rejection. Small studies have been performed in the past for better assessment of pathogenesis for graft rejection immunology. We have used a combination of established immunologic assessment methods to improve the predictability of post-transplant graft function and thereby guide the management of immunosuppression.