T cell receptor altered peptide ligands of Myelin Basic Protein and Proteolipid Protein (Linear and Cyclic) can modulate immune responses in SJL/J mice: Bioactive peptides for Multiple Sclerosis

摘要

Multiple Sclerosis (MS) is commonly occurring chronic, inflammatory and disabling disorder of the central nervous system (CNS). It affects 0.05-0.15% of Caucasians with the onset of the disease in young adulthood and women with the disease outnumber men two to one [1]. CD4+ type 1 T helper cells are widely considered to play a pivotal pathological role in mediating an autoimmune attack against components of myelin sheath. Recent studies have challenged the idea that more cells, such as CD8+ T cells, macrophages and complement are also responsible for axonal damage and neurodegeneration [2-5]. Myelin Basic Protein (MBP), Proteolipid Protein (PLP) and Myelin Oligodendrocyte Glycoprotein (MOG), have been demonstrated to be encephalitogenic in humans and rodents [5].