O-Acyl isopeptide method for peptide synthesis: Application of O-acyl isodipeptide units to the synthesis of bioactive peptides

摘要

Solid-phase peptide synthesis (SPPS) has been routinely used for chemical synthesis of peptides. However, the synthesis of "difficult sequence"-containing peptides is one of the most problematic areas in peptide chemistry, and these peptides often have low solid-phase synthetic yield and purity due to their hydrophobic and aggregative properties.