D-4F Does Not Mitigate Key Parameters in Rat Model of Severe Pulmonary Hypertension

摘要

We employed a newly developed rat model of severe pulmonary hypertension (PH) to study if treatment with apolipoprotein (apo)-mimetic peptide, D-4F, mitigates PH and related pathology. Sprague-Dawley rats underwent surgery to partially ligate their left pulmonary artery, after 3-days they were injected with monocrotaline (MCT) and then randomly selected to receive a daily injection of D-4F or saline. After 21-days of treatment the animals were examined with respect to isolated lung hemodynamic measurements and X-ray microfocal angiography. There was no significant difference in right-to-left heart weight, change in body weight, pulmonary vascular resistance (PVR), or pulmonary micro-vascular density between D-4F and saline treated rats.