Efficient Catalytic Asymmetric Synthesis of alpha-Substitnted Phenyloxyacetyloxy and Aroyloxy Phosphonates

摘要

Optically active alpha-substituted phenoxyacetyloxy and aroyloxy phosphonates have been synthesized via catalytic asymmetric hydrogenation of the corresponding prochiral a, p-unsaturatedphosphonates using Rh(I)/(R,R)-Me-DuPhos as the catalyst in methanol at 18 deg C. The asymmetrichydrogenation reaction exhibits excellent enantioselectivity with enantiomeric excesses from 91% to96%.