METHIOCARB (132)

摘要

Methiocarb, an insecticide, acaricide, molluscicide and bird repellent, was first reviewed by the Meeting in 1981. Since then it was evaluated in 1983, 1984 (toxicology), 1985 (toxicology), 1986 (residue), 1987 and 1988 (residue). It was reviewed under the Periodic Review Program in 1998 for toxicology and in 1999 for residue. The 1998 JMPR allocated a new ADI of 0-0.02 mg/kg body weight and ARfD of 0.02 mg/kg body weight. It noted that methiocarb sulfoxide, as well as methiocarb, is of acute dietary concern. The 1999 JMPR reviewed information and data on identity, metabolism and environmental fate, methods of residue analysis, use pattern, residues resulting from supervised trials, fate of residues in storage and processing, residues in food in commerce or at consumption, and national maximum residue limits and concluded that the residue should be defined both for enforcement of MRLs and for the estimation of dietary intake as "the sum of methiocarb, methiocarb sulfoxide and methiocarb sulfone, expressed as methiocarb". It estimated provisional maximum residue levels and STMRs for strawberry, leek, cabbages, cauliflower, cucumber, melons, pepper, tomato, pea, maize and hazelnuts. However, due to lack of appropriate storage stability studies covering a period of 1 month to 2 years corresponding to the actual storage period in supervised trials, the 1999 JMPR decided to withdraw the existing Codex MRLs for the above-mentioned commodities (except strawberry) and other commodities for which no data had been submitted to the Meeting; however, it did recommend a new maximum residue level for strawberry.