Chemical constituents of the plants of the genus Cleistanthus and their biological activity

摘要

Chemical examinations of Cleistanthus collinus Roxb.,a poisonous tree from India,and Cleistanthus patulus Muell.Arg.have resulted in isolation of a number of arylnaph-thalide lignans and their glycosides as well as some furofuranoid lignans.While Cleistanthus gracilis Hook.f.from Thailand afforded an unusual glucoside of 2-beta-hydroxy-8-azabicyclo-(5,0,2)-4beta,9beta-epoxynona-5,7-diene,C.schlechteri from South Africa was the first reported source of the pimarane diterpenes.Cleistanthin A and cleistanthin B,diphyllin glycosides isolated from C.collinus were reported to exhibit cytotoxicity on several cancer cell lines.Cleistanthin A was found to cause DNA strand breaks and induce apoptosis in cultured cells while cleistanthin B caused G1 arrest and induced apoptosis in mammalian cells.