Investigating the Effect of Adding Drug (Lidocaine) to a Drug Delivery System Using Small-Angle X-Ray Scattering

摘要

The effect on a model drag delivery system when adding a drag, lidocaine, has been studied. Temperature and concentration dependence of a nonionic micro-emulsion with part of the oil, 1 and 10 vol. %, substituted with drag has been investigated. A nonionic oil-in-water microemulsion consisting of CH_3(CH_2)_(11)(OCH_2CH_2)_5OH, (C_(12)E_5), decane, water and the drag (lidocaine) that has been used to substitute part of the oil was studied. The microscopic differences have been derived from small-angle X-ray scattering (SAXS) data and the results are compared with light scattering data. Using these results together with the macroscopic differences, as observed in the phase diagram (lowering of phase boundaries), between the systems with and without lidocaine can be explained.