BIO-SYNTHESIS OF STABLE ISOTOPES LABELLED THYROID HORMONES PRECURSOR

摘要

The research realized in our laboratory is part of a global project to develop a new tool for the thyroid metabolism studies using stable isotope metabolic probes. The purpose of this part was to study a production mode of L-tyrosine labelled with stable isotope (carbon 13, nitrogen 14 and/or oxygen 18). A bacterial strain has been selected and two techniques were investigated, compared and optimized in terms of conversion yield and productivity: biosynthesis with free or encapsulated biomass in batch processes.