ASSIGNING THE POSITION OF RADIOLABELLING WITHIN TRITIATED BIOMOLECULES BY ACCURATE MASS USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

摘要

The specificity of certain tritium labelling techniques varies depending on the molecule being labelled. We regularly observe site specific labelling methods that produce additional, non-specific labelling within the molecule. It is of significant interest to determine the position of this extra labelling.