Recent developments in methodology enable us to extend the density-functional theory approach, that primarily focuses on the self-consistent electronic structure, to poly-atomic complexes with 10,000 and more atoms, atomic motion over time scales of seconds, and involved statistics. In this contribution we will sketch recent density-functional theory-based hybrid methods, which bridge the length and time scales from those of electron orbitals to meso- and macroscopic proportions, and present some results for crystal growth and the self-assembly of nano-scale structures.
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