Fungicide resistance and aflatoxin production; the effect of resistance mutations to triazoles, phenylpyrroles and anilinopyrimidine fungicides on aflatoxigenic ability of Aspergillu s parasiticus

摘要

Aflatoxins are highly toxic secondary metabolites, predominantly produced by Aspergillus flavus and A. parasiticus. The contamination of food and feed by mycotoxigenic fungi is a serious worldwide health hazard to both human and livestock (Chu, 2002).An approach for the control of mycotoxigenic fungal species should be the use of appropriate antifungal agents (Buchanan et al., 1987; Badii & Moss, 1988; D'Mello et al., 1998). However, like other many organisms, these fungal species may become resistant ,to fungicides. In this case, an important consideration is the influence of fungicide resistance mutations on the mycotoxigenic ability of mutant strains. To our knowledge no information is available concerning the risk for resistance development tofungicides in A. parasiticus and the impact of these mutation(s) on mycotoxin production. The research reported here was co-funded by the European Social Fund and National Resources - EPEAEKII.