(667e) Short and Long-Term Changes in Circulatory Protein and Cytokine Profiles Following Burn and CLP Treatments

摘要

Bums and trauma lead to a hypermetabolic state characterized by an accelerated breakdown of skeletal muscle protein in the patient which leads to muscle wasting and reduction of lean body Since burn patients in general experience a breakdown in gut barrier function that causes bacterial translocation into the body, patients that develop septic complications exhibit a prolonged hypermetabolic state which is triggered by a systematic inflammatory response. This inflammatory response is mediated by circulatory cytokines or proteins, which in turn might affect the signal transduction in liver resulting in changes in gene expression profiles, which plays an important role in hypermetabolic state. Although some inflammatory cytokines expressed in liver or circulated in the blood, such as ILl-a, IL-2, IL-6, IL-10 and TNF-a, have been extensively studied following thermal injuries (Gauglitz et al. 2008; Klein et al. 2003; Summer et al. 2008), more comprehensive analysis given the dynamic behaviors of all possible inflammatory proteins after bum injury or sepsis is required.