Complex Dynamics in Tumor Gene Regulatory Networks: Oncogenesis Dynamics Driven by 'Genes Gone Crazy'

摘要

Human neoplasms are considered to be diseases whose pathogenesis is attributed to genomic aberrations. Yet, it has been previously reported that genomic stability is probably not the sole "player" in tumor ontogenesis. Several genes have been identified that are considerd to be the "oncogenic drivers". In that sense the present work manifests a hypothesis that tumor ontogenesis could be driven by genes or network of genes that get out of control or else "genes gone crazy".