Preparation of Calcium Phosphate Coated Simvastatin-Loaded PLGA Microspheres Dispersed Alginate Hydrogel Beads as a Controlled Drug Delivery Carrier

摘要

Simvastatin (SIM) is widely used as a cholesterol-lowering drug known to affect bone formation in vivo and its sustainable administration into localized area is of particular interest. We reported previously that sustained SIM release from poly (lactic-co-glycolide) (PLGA) microspheres could maintain relatively low concentration in the bone defect area, resulting in the improved bone regeneration effect. The aim of this study was to determine the release characteristics of SIM from calcium phosphate coated SIM-loaded PLGA Microspheres (CSPMs) dispersed into an alginate hydrogel bead (with different drug release profiles), since we speculated that further sustainable SIM release would be more effective related to stimulate the formulation of BMP-2, resulting in the promoted bone regeneration.