Fundamental In-vitro Hemodynamic/Hemorheologic Study for the Pathogenetic Investigation on Cardiovascular Disorder

摘要

To investigate detailed hemodynamic information through a stentic lesion can provide us the fundamental pathogenetic information related to thrombosis formation which plays major role to cardiovascular disorders. Generally hemodynamic and hemorheologic features near vessel wall is well known as most important key factors for thrombosis generation. Especially, hemodynamic behavior on the stenotic lesion growth may be affected by the recirculation region of blood flow downstream through the stenosis of blood vessel and the geometrical characteristics on the blood vessel alignment. From this sense, in-vitro experiments were carried out using blood vessel models with different alignment angle made of PDMS micro-channel based on patient's angiogram with stenotic lesion in right coronary artery. The hemodynamic feature was investigated using high resolution micro PIV technique. The red blood cells were used as tracer particles for instantaneous velocity profile measurement based on cross correlation method.