Pharmacokinetics of Cephapirin Sodium in Milk Using an 8-day Extended Therapy Program of Daily Intramammary Infusion in Healthy Lactating Holstein-Friesian Cows

摘要

Cephapirin (CEPH) is a frequently administered intramammary (IMM) treatment for clinical mastitis in the U.S. (Sawant et al., 2005; Pol and Ruegg, 2007; USDA, 2009). The current label claim for IMM CEPH (200 mg) is 2 treatments 12 h apart with 96 h ofmilk withhold after the last treatment. A large percentage of dairy farms milk cows three times per day (3X) making 12 h IMM treatment intervals impractical. Additionally, to reduce residue risk, many dairy farmers desire to administer IMM therapy one time per day when hospital personnel are present.