DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF MANNOSE-BASED GLYCODENDRIMERS AS POTENT DC-SIGN ANTAGONISTS FOR DENGUE INFECTION

摘要

DC-SIGN is a C-type lectin expressed on dendritic cells. It contains four Ca2+- dependent carbohydrate recognition domains that specifically recognize complex mannose glycans present on the surface of invading microorganisms. For some pathogens, including viruses like HIV, Ebola or Dengue,[1] this recognition event contributes to infection transmission, making DC-SIGN a very interesting target for the design of antiviral agents.