Minimally Invasive Treatment of Bone Metastasis (interventional procedures)

摘要

Metastatic bone lesions are common problem among patients with advanced cancer, this problem concerns 30% of all cancer patients and 50-75% from them will suffer significant pain. Pain is caused by stretching of the periosteum by tumor and nerve stimulation in the endosteum. Sensitization of the neural tissue is mediated by cytokines, local growth factors, peptides similar to parathyroid hormone and prostaglandins, potassium ions, bradykinin and osteoclast activating factors. Painful stimuli are transmitted by C and A delta fibres [1,4]. The incidence of bone metastases are particularly common among patients suffering from: breast cancer (90%), prostate 65-75%, thyroid 60%, myeloma 70-90%, lung 30-40%, kidney 20-25%, melanoma 15-45% [2].