Good results after D2 gastrectomy in western advanced N0 gastric cancer patients: a multicentric analysis

摘要

The records of 301 patients who underwent curative gastrectomy for gastric carcinoma and were adequately staged as N0 between 1995 and 2002 were retrospectively analyzed, under the auspices of the Italian Study Group for Gastric Cancer. Disease specific and disease free survival after 3, 5 and 10 years were 90.4%, 86.1%, 75.9% and 72.1%, 57.3%, 57.3%. Thus, survival was similar to that previously reported by Eastern Centers. Mortality was 1.7%. The factors associated with a better disease-specific survival at univariate analysis were age<60, T2 tumors, distal location, intestinal histotype and number of retrieved nodes>25; depth of infiltration and histotype were the only 2 independent predictors of 5 year recurrence free survival at multivariate analysis. These parameters must be considered to stratify node-negative gastric cancer patients for an adjuvant treatment and for follow-up scheduling.