Ribosomal Synthesis of γ-Amino Acid-Containing Cyclic Peptides

摘要

Here we report a new strategy to ribosomally synthesize cyclic peptides containing various γ-amino acids. In this methodology, the expressed peptides in an engineered translation system containing N-terminal γ-amino acid undergo thioester formation via N-S acyl-shift followed by spontaneous macrocyclization.