In Vitro Response of MC3T3-E1 Osteoblast-like cells to Synthetic Proline-rich Peptides

摘要

Hard tissue formation occurs by a process of matrix-mediated biomineralization in which intracellular and extracellular organic proteins regulate the initiation, growth and deposition of mineral crystals. Among the extracellular proteins that regulate biomineralization are several molecules that exhibit proline-rich regions, like collagens, amelogenins, ameloblastin and sialoproteins. The proline-rich regions have remained remarkably well-conserved through evolution, suggesting that they may have functional importance.