PHARMACOKINETIC STUDIES OF A NOVEL THIAZOLIDINEDIONE MITONEET LIGAND, NL-1, USING A QUANTITATIVE LC-MS/MS METHOD IN DOSED MOUSE SERUM AND BRAIN

机译：用定量LC-MS / MS法在给药血清和脑中的定量LC-MS / MS法，新型噻唑烷二酮型Mitoneet配体，Nl-1的药代动力学研究

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This is the first LC-MS/MS method for determination of NL-1. A noted carryover problem was addressed by adding ammonium acetate to the mobile phase. The present method is accurate, precise, robust and reproducible. NL-1 shows rapid distribution and metabolism kinetics in blood and brain in mice.

机译：这是用于确定NL-1的第一个LC-MS / MS方法。通过将醋酸铵添加到流动阶段来解决已注意的核心问题。本方法精确，精确，稳健和可重复。 NL-1显示了小鼠血液和脑中的快速分布和代谢动力学。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2013年||共1页
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Kiran K. Pedada; Xiang Zhou; Harini Jogiraju; Richard T. Carroll; Werner J. Geldenhuys; Li Lin M.S.; David J. Anderson;
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中图分类 TB994.5-53;
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1. A quantitative LC-MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies [J] . Kiran K. Pedada, Xiang Zhou, Harini Jogiraju, Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2014,第Null期

机译：定量LC-MS / MS方法测定适合药代动力学研究的小鼠血清中的噻唑烷二酮mitoNEET配体NL-1
2. A validated LC-MS/MS method for quantitative analysis of curcumin in mouse plasma and brain tissue and its application in pharmacokinetic and brain distribution studies [J] . Prakash Ramalingam, Young Tag Ko Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2014,第Null期

机译：经过验证的LC-MS / MS方法定量分析小鼠血浆和脑组织中的姜黄素及其在药代动力学和脑分布研究中的应用
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机译：经过验证的LC-MS / MS方法可同时定量测定小鼠血浆和大脑中白藜芦醇的含量，并将其应用于药代动力学和大脑分布研究
4. PHARMACOKINETIC STUDIES OF A NOVEL THIAZOLIDINEDIONE MITONEET LIGAND, NL-1, USING A QUANTITATIVE LC-MS/MS METHOD IN DOSED MOUSE SERUM AND BRAIN [C] . Kiran K. Pedada, Xiang Zhou, Harini Jogiraju, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：用定量LC-MS / MS法在给药血清和脑中的定量LC-MS / MS法，新型噻唑烷二酮型Mitoneet配体，Nl-1的药代动力学研究
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7. Validation of a LC-MS/MS Method for Quantitative Analysis of MELK Inhibitor OTS167 in Mouse Serum: Application to a Pharmacokinetic Study [O] . Wei Peng Yong, Vinod Vijay Subhash, Mitchell Qin-Ying Ee, 2018

机译：验证小鼠血清麦克抑制剂OTS167定量分析的LC-MS / MS方法：对药代动力学研究的应用

PHARMACOKINETIC STUDIES OF A NOVEL THIAZOLIDINEDIONE MITONEET LIGAND, NL-1, USING A QUANTITATIVE LC-MS/MS METHOD IN DOSED MOUSE SERUM AND BRAIN

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