Key contribution of post-transcriptional mechanisms to circadian metabolism regulation revealed by Perseus analysis of quantitative proteomics and cross-omics data

摘要

At least 6% of the proteome shows circadian oscillations in liver 1/3 of cycling proteins have no corresponding cycling transcript Phases of cycling proteins form two distinct clusters. mRNA are more evenly distributed over the whole day mRNA/protein time lag is not constant Circadian posttranscriptional and posttranslational mechanisms play a key role in the temporal orchestration of liver metabolism and physiology