Shvo's catalyst in chemoenzymatic dynamic kinetic resolution of amines Inner or outer sphere mechanism?

摘要

The interception of both 3 and 5 as abundant key intermediates as well as the temporal accumulation of 11 in detriment of 5 in the Casey-like trapping reaction gives therefore support for the thermal dissociation of the Shvo's catalyst 1 as well as for the inner-sphere H-transfer mechanisms with metal coordination in 3 of the amine and therefore the key participation of intermediate 5.