Quantitative Proteomics Analysis of Human Adenovirus Infections by iTRAQ-8plex

摘要

Adenoviruses (Ads) are self-organizing and the full complexity of Ads is unfolded as soon as they interact with host cells. They associate with respiratory and gastrointestinal tract infections. In addition, they are the most common viral vectors in clinical gene transfer trials. Although studies of Ad-host interactions have emerged as a key driving force in the research of infectious diseases, our understanding of the systems properties of Ad infections has remained incomplete. To address the unsolved issues, we anticipate our quantitative proteomics and known network interactions together with mathematical models to find out deep insights into Ad-host complex interactions. These may lead to the identification of key viral and host genes driving the infectious Ad life cycle.