AUTOMATED FLUIDIC SYSTEM WITH A CHAOTIC MICROFLUIDIC REACTION CHAMBER FOR RAPID, MULTI-ANALYTE IMMUNOSENSING

摘要

In this paper, a fully automated fluidic system with a chaotic reaction chamber for rapid and accurate fiber-optic immuno-sensing has been developed and applied for the measurement of cardiac biomarkers. A new microchannel with serpentine bump structures has improved the sensor performance by generating local turbulence near the sensor surface. A full immunoassay with the automated fluidic system has been successfully performed, and the total assay time spent for detecting four cardiac markers was less than 10 minutes.