Primary sclerosing cholangitis: bile duct and colonic carcinomas after long-term ursodeoxycholic acid

摘要

Primary sclerosing cholangitis (PSC) is characterized by progressive fibrosing inflammation of the bile ducts leading to cholestasis and finally to cirrhosis of the Hver. The disease is frequently associated with ulcerative colitis. A problem lies in the increased incidence of cholangiocarcinomas and colonic carcinomas and, according to a recent study, also pancreatic carcinomas.