TEAD1: YIN AND YANG OF THE CELL REGULATION

摘要

TEAD transcription factors mediate gene expression regulation through interactions with their DNA response M-CAT motif. They are active during growth and development and activate gene expression of proteins responsible for cell proliferation, differentiation or apoptosis. To understand the principles of interaction between TEAD1 and M-CAT motifs originating from regulatory regions of human genes, several structural mass spectrometry techniques were used.