NANOSTRUCTURED TUNGSTEN OXIDE SUBSTRATE WITH OXYGEN VACANCIES FOR EFFICIENT SURFACE-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY ANALYSIS

摘要

The development of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) for characterizing molecules was a significant breakthrough that build upon the 2002 Nobel-prize winning studies of Tanaka on soft desorption ionization methods for mass spectrometric analysis. While the vacuum environment and matrix preparation make the method timeconsuming and laborious, ambient ionization mass spectrometry is becoming increasingly attractive because of its simple sample pretreatment process. More than 40 ambient ionization methods have been developed since 2004 and surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is a very important branch in the ambient MS analysis. The search for more sensitive, versatile, and robust substrate for SALDI-MS becomes particularly important.