TAPE STRIPPED STRATUM CORNEUM SAMPLES PROVE TO BE SUITABLE FOR COMPREHENSIVE PROTEOMIC INVESTIGATION OF ACTINIC KERATOSIS

摘要

Actinic keratoses (AK) are frequent premalignant tumors that can be clinically difficult to differentiate from skin cancer. To definitely confirm or rule out the diagnosis, a biopsy is needed, but this is an invasive procedure that leads to increased morbidity. An easy, quick and reliable non-invasive alternative to biopsy is needed to definitively confirm the clinical diagnoses. In this paper, we evaluate Tape Stripping (TS) of stratum corneum (SC) for biomarker analysis of AK.