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MASS SPECTROMETRIC CHARACTERIZATION OF A POLYMERIC DEGRADATION PRODUCT FORMED FROM THE ANTIBIOTIC CEFTAZIDIME

机译：抗生素头孢他啶形成的聚合物降解产物的质谱表征

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Degradation products in pharmaceuticals may cause harmful side effects but the new substances generated may have different therapeutic activities. Ceftazidime is a β-lactam antibiotic, which polymerizes during normal storage conditions [1]. Ceftazidime polymer showed a high inhibitory effect on HIV-1 reverse transcriptase [2,3]. In this study mass spectrometry is applied with the objective of revealing the chemical structure of a cefatzidime polymer.

机译：药物中的降解产物可能导致有害的副作用，但产生的新物质可能具有不同的治疗活动。头孢他啶是一种β-内酰胺抗生素，其在正常储存条件下聚合[1]。 CeTtazidime聚合物对HIV-1逆转录酶进行了高抑制作用[2,3]。在该研究中，施用质谱，目的是揭示CeFatzidime聚合物的化学结构。

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《International Mass Spectrometry Conference》|2018年|p628-1245|共2页
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Anna Maria Alves de Piloto Fernandes; Nilton Soares Camilo; Elias Paulo Tessaro; Marcos N. Eberlin;
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正文语种
中图分类分析化学;
关键词
ceftazidime; Anti-HIV-1 activity; degradation products; β-lactam antibiotic;

机译：头孢他啶;抗HIV-1活性;降解产品;β-内酰胺抗生素;

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MASS SPECTROMETRIC CHARACTERIZATION OF A POLYMERIC DEGRADATION PRODUCT FORMED FROM THE ANTIBIOTIC CEFTAZIDIME

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