Stressor-induced proteome alterations in zebrafish: a meta-analysis of response patterns characterized by gel-based and gel-free proteomics

摘要

Similar proteome responses to different stressors are commonly seen in zebrafish as well as in other species. Most often detected groups include cytoskeleton, energy metabolism and stress response proteins, followed by a much scarcer representation of other proteins. Thus, the usefulness of global proteomics for deciphering chemical-specific mechanisms appears rather limited at the moment. Thus, current proteomics methodology needs further development to allow increasing the routinely achieved coverage.