Proteomics Analysis of Toxoplasma gondii Palmitoylated Proteins and its Impact on Rhoptry Localization

摘要

T. gondii palmitoylome reveals that this post-translational modification is widespread and a general mechanism of dynamic protein regulation that affects vital processes of this parasite. ABE Is an efficifent method of choice to identify palmitoylated proteins. The fact of having found nucler palmitoylated proteins is exciting and deserves to be studied in more detail. Furthermore, the identification of palmitoylated proteins in different components of the host-cell invasion machinery (mainly rhoptries but also IMC, micronemes and even dense granules) suggests a key role of this modification in the invasion process.