Thermodynamics and kinetics study of individual K~+ binding events reveal new aspects of DNA G-quadruplex folding pathways

摘要

G-quadruplex (G4) = Particular DNA structure, constituted by the stacking of quartets (four guanines interacting via Hoogsteen hydrogen bonds). Proposed as arti-cancer targets because of their influence on oncogene transcription (promoter quadruplexes) and the maintenance of the chromosomes (telomeric quadruplexes).