Impact of isomeric differences between internal standard and analyte for the LC-MS/MS quantification of 11-Nor-delta9-THC-9-carboxylic acid glucuronide

摘要

Despite isomeric differences, (±)-cis-THC acid-D3-glucuronide is shown to be an appropriate internal standard for the LC-MS/MS quantification of (+)-trans-THC acid glucuronide under the listed experimental conditions. The impact of isomeric differences between internal standard and analyte on LC-MS/MS quantification is compound-specific and must be assessed prior to analysis.