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Development of an ultra-sensitive, high-throughput Multiplexed LC(HILIC)-MS/MS method for the simultaneous quantitation of naloxone, buprenorphine, and norbuprenorphine

机译：开发超敏感的高通量复用LC（HILIC）-MS / MS方法，用于同时定量纳洛酮，丁丙诺啡和Norbuperphine

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摘要

A robust, high sensitivity and high throughput bioanalytical method for naloxone, buprenorphine and norbuprenorphine was developed, validated and applied successfully to clinical sample analysis. The compensated characteristics of liquid-liquid extraction and HILIC chromatography were integrated to develop a sensitive, efficient and robust bioanalytical method.

机译：开发，验证和应用于培养基，培丙酮，丁甲啡和Norbuperphine的鲁棒，高灵敏度和高通量生物分析方法，验证并成功地应用于临床样本分析。液 - 液提取和HILIC色谱的补偿特性被整合为发育敏感，有效且稳健的生物分析方法。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2014年||共1页
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Xiaodong Zhu; Thomas Horvath; Jingguo Hou; Edward Wells; Steve E. Unger;
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中图分类 TB994.5-53;
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1. Simultaneous determination of buprenorphine, norbuprenorphine and naloxone in human plasma by LC-MS-MS [J] . Chiang T.-Y., Pao L.-H., Hsiong C.-H., Chromatographia . 2011,第7a8期

机译：LC-MS-MS同时测定人血浆中的丁丙诺啡，去甲丁丙诺啡和纳洛酮
2. Simultaneous Determination of Buprenorphine, Norbuprenorphine and Naloxone in Human Plasma by LC-MS-MS [J] . Ting-Yi Chiang, Li-Heng Pao, Cheng-Huei Hsiong, Chromatographia . 2011,第7a8期

机译：液相色谱-质谱-质谱法同时测定人血浆中的丁丙诺啡，去甲丁丙诺啡和纳洛酮
3. Development and validation of a high-throughput and robust LC-MS/MS with electrospray ionization method for simultaneous quantitation of oseltamivir phosphate and its oseltamivir carboxylate metabolite in human plasma for pharmacokinetic studies. [J] . Kanneti R, Bhavesh D, Paramar D, Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2011,第6期

机译：开发和验证具有电喷雾电离方法的高通量且功能强大的LC-MS / MS，用于同时定量人血浆中的磷酸奥司他韦及其羧酸奥司他韦羧酸酯代谢物，用于药代动力学研究。
4. Development of an ultra-sensitive, high-throughput Multiplexed LC(HILIC)-MS/MS method for the simultaneous quantitation of naloxone, buprenorphine, and norbuprenorphine [C] . Xiaodong Zhu, Thomas Horvath, Jingguo Hou, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：开发超敏感的高通量复用LC（HILIC）-MS / MS方法，用于同时定量纳洛酮，丁丙诺啡和Norbuperphine
5. LC-MS/MS Method Development for the Quantitation of Methylmalonic Acid Using Aqueous Normal Phase Chromatography [D] . Biocini, Daniel Joseph. 2020

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6. Development and validation of a high throughput LC–MS/MS method for simultaneous quantitation of pioglitazone and telmisartan in rat plasma and its application to a pharmacokinetic study [O] . Pinaki Sengupta, Bappaditya Chatterjee, Uttam Kumar Mandal, 2017

机译：高通量LC-MS / MS方法的开发和验证可同时定量大鼠血浆中的吡格列酮和替米沙坦及其在药代动力学研究中的应用
7. Development and validation of a bioanalytical method for the simultaneous determination of heroin, its main metabolites, naloxone and naltrexone by LC–MS/MS in human plasma samples: Application to a clinical trial of oral administration of a heroin/naloxone formulation [O] . Raquel Moreno-Vicente, Zuriñe Fernández-Nieva, Arantza Navarro, 2015

机译：LC-MS / MS在人血浆样品中同时测定海洛因，其主要代谢产物，纳洛酮和纳罗酮和纳曲酮的生物分析方法的发展与验证：应用于海洛因/纳洛酮制剂口服施用的临床试验
8. Novel Method for the Determination of Sildenafil (Viagra) and Its Metabolite (UK-103,320) in Postmortem Specimens Using LC/MS/MS and LC/MS/MS/MS [R] . Lewis, R. J., Johnson, R. D., Blank, C. L. 2000

机译：使用LC / ms / ms和LC / ms / ms / ms测定死后标本中西地那非（伟哥）及其代谢物（UK-103,320）的新方法

Development of an ultra-sensitive, high-throughput Multiplexed LC(HILIC)-MS/MS method for the simultaneous quantitation of naloxone, buprenorphine, and norbuprenorphine

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