Mass Spectrometry Identification of Membrane Interacting Peptides Suggests Membrane Topology of NADPH-cytochrome P450 oxidoreductase and Cytochrome P450 46A1

摘要

1. The membrane interacting sequences appear in every domain of CPR suggesting various modes of CPR interaction with the membrane. Multiple membrane interacting areas assumes inter-domain motion as an important function for CPR. 2. The membrane interacting site of CYP46A1overlaps with the entrance to the substrate access channel proposed from crystal structure.