Intrapartum Exposure to Tobacco Smoke: Is There a Relevance to Neonatal Fibrinolysis and Coagulation Disturbances?

摘要

Both clinical and experimental research have linked smoking to disturbances of coagulation and fibrinolysis. Several potential mechanisms are incriminated, involving inflammation, fibrinogen synthesis and clotting factors. Based on the fact that most of tobacco components cross the placent,we performed a prospective analysis on the haemostatic profile of neonates exposed in utero to tobacco smoke. The study was based on the comparative evaluation of coagulation and fibronolysis between infants of women who smoke in pregnancy and a control group. Results revealed no significant alterations in coagulation and fibrinolytic parameters.