Correlation between texture and tabletting properties of some pharmaceutical tablets

摘要

A compaction simulator and a hydraulic press were used to compact single-component tablets from six different pharmaceuticals. These pharmaceuticals had different compaction behaviour and the correlation between the tabletting properties and the preferred orientation were studied. Most of the studied materials were texturized in compression and the degree of the texture appeared to be dependent on the compaction behaviour of the material. The plastic and brittle materials had clear texture but the elastic sample was not texturized. The compaction pressure had no effect on the orientation of the crystals but the pole figures were smoothed slightly when the pressure was increased. It is suggested that the texture of pharmaceuticals may affect e.g. the dissolution properties of the tablets and based on the present study the texture analysis will offer a potential new research tool for pharmaceutical physicists to study tablets.