THE RELATIONSHIP BETWEEN UNDERLYING HEARTRHYTHM AND INDUCIBILITY OF VENTRICULARFIBRILLATION IN BRUGADA SYNDROME

摘要

Background; However the inducibility of ventricular fibrillation (VF) during electrophysiological study (EPS) may be useful for the risk stratification in Brugada syndrome; it is difficult to induce VF even with drug administration, i.e. class lc drugs. On the other hand atrial fibrillation (AF) is also popular in Brugada syndrome, the electrical disorder might exist both in the atrial and ventricular muscle. We compare the inducibility of VF by programmed pacing between during sinus and AF rhythm. Methods and Results; Three patients of Brugada syndrome had been performed EPS to induce VF. Patient 1 and 2 have a typical ECG pattern with Brugada syndrome. Patient 1 and 3 had syncope. VF was not induced by programmed pacing during sinus rhythm even by the administration of class lc drug in all of the 3 cases. In contrast, AF was induced by atrial programmed pacing easily. After inducing AF, VF requiring direct current shock was induced easily and reproducibly in all of 3 cases. Conclusions; We report three cases of Brugada syndrome whose VF was induced only during AF, but not during sinus rhythm. These results indicate that VF might be induced easily during AF rather than sinus rhythm in Brugada syndrome.