MECHANISMS OF SHOCK-INDUCED ARRHYTHMOGENESIS:ROLE OF TISSUE DISCONTINUITY AND ELECTROPORATIONIN THE INITIATION OF FOCAL REPETITIVE POSTSHOCKACITVATIONS

摘要

Ventricular fibrillation induction or re-initiation following electric shocks is preceded by focal repetitive postshock activations (RPAs); however, their mechanisms underlying this behavior remain unclear. In a 1-dimensional bidomain fiber model, we demonstrated (hat oscillations in membrane potential are regulated by electroporation and the strength of electrotonic influences in the fiber, and depend on fiber length. In a 2-dimensional sheet model, focal RPAs occurred following electroporation-induced afterdepolarization-like oscillations and were regulated bv the distance between lines of discontinuitv.