There are discrepancies between simulations and experiments in the transmembrane potential changes ( (DELTA)V_m ) by strong electric shocks. We found that the experimentally-observed (i) negative bias in (DELTA)V_m asymmetry (asymmetry ration approx = 2), (ii) rectangularly-shaped positive (DELTA)V_m , (iii) electroporation occurring at the anode only, and (iv) increase in positive (DELTA)V_m caused by the L-type Ca~(2+)-channel blockade were reproduced in the model by the addition of electroporation and a hypothetical outward current, the latter assumed to be part of the K~+ flow through the L-type Ca~(2+)-channel.
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